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Thematic IV - Inflammation and gastrointestinal motility
Goals | Publications | Books | Book chaptersParticipants:
Francisco de Assis A.Gondim, Armênio A. dos Santos, Francisco Hélio Rola, Gerly A. de Castro Brito, Ivna Hitzschky S. dos F. V. Previdelli, Marcellus H. Loiola Ponte de Souza, Miguel Ângelo CPF, Pedro Jorge C. Magalhães, Pedro Marcos G. Soares, BSPharm, Vicente de Paula T. Pinto, Ricardo Brandt de Oliveira, Vicente Paulo T. Pinto, Sifrim, D - University of Leuven -BEL, and Knowles, C. London-UK.
The fourth thematic (Inflammation and gastrointestinal motility) included five goals from which we give the following achievements during the year 2009:
Goals:
Modulation of the inflammatory response, as threrapeutic strategy to revert the digestive motility alterations, associated with chemotherapy-induced mucositis
Study of the prevalence and diagnostic of neurologic diseases in the SemiArid
Investigate the contractility of the smooth muscle of the gastric fundus and duodenum in vitro induced by KCl, serotonine, carbacol or electrical stimulation from rats or mice pre-treated with 5-FU or irinotecan.
Study the pharmacological characteristics of terpenos (alfa and beta-pireno as well as others), found in plant oils from the Northeastern Semiarid, applied to the gastrointesinal tract.
Investigate whether self-antibodies against enteric ionic channels are present and/or whether are useful for diagnosis of patients with DNMGI. Investigate if the self-antibodies (if present) are pathogenic
Contribute to elucidate the expression profile of ionic channels in the enteric neuromuscular layers, including CIC
Publications
i. Barbosa, A. L. R. ; Pinheiro, C. A. ; Oliveira, G. J. ; Moraes, M. O. ; RIBEIRO, R. A. ; VALE, M. L. ; Souza, M. H. L. P. . Tumor bearing decreases systemic acute inflammation in rats role of mast cell degranulation. Inflammation Research, p. 1-2, 2009.
ii. Gomes, Antoniella Souza ; Lemos, Henrique Paula ; Medeiros, Jand Venes Rolim ; Cunha, Fernando Queiroz ; Souza, Marcellus Henrique Loiola Ponte . Lipopolysaccharide from Escherichia coli prevents indomethacin-induced gastric damage in rats: role of non-protein sulfhydryl groups and leukocyte adherence. Inflammation Research, p. 10-11, 2009.
iii. Medeiros, J. V. R ; Bezerra, V. H ; Gomes, A. S ; Barbosa, A. L. R ; Lima-Junior, R. C. P ; Soares, P. M. G ; Brito, G. A. C ; Ribeiro, R. A ; CUNHA, F. Q. ; Souza, M.HL P. Hydrogen sulphide prevents ethanol-induced gastric damage in mice: role of katp channels and capsaicin-sensitive primary afferent neurons. Journal of Pharmacology and Experimental Therapeutics, p. 2, 2009.
iv. Murad-Regadas, Sthela M. ; Regadas, Francisco Sérgio P. ; Rodrigues, Lusmar V. ; Oliveira, Leticia ; Barreto, Rosilma G. L. ; Souza, M. H. L. P. ; SILVA, F. R. S. . Types of pelvic floor dysfunctions in nulliparous, vaginal delivery, and cesarean section female patients with obstructed defecation syndrome identified by echodefecography. International Journal of Colorectal Disease , v. 24, p. 1227-1232, 2009.
v. Souza, M. A. N. ; Souza, M. H. L. P. ; Palheta, R. C. ; Cruz, P. R. M. ; MEDEIROS, B. A. ; ROLA, F. H. ; Magalhaes, P. J. C. ; TRONCON, L. E. A. ; SANTOS, A. A. . Evaluation of gastrointestinal motility in awake rats: a learning exercise for undergraduate biomedical students. Advances in Physiology Education, v. 33, p. 343-348, 2009.
vi. Souza Filho, M.V.P. ; Loiola, R.T. ; Rocha, E.L. ; Simão, A.F.L. ; Gomes, A.S. ; Souza, M. H. L. P. ; RIBEIRO, R. A. . Hind limb ischemic preconditioning induces an anti-inflammatory response by remote organs in rats. Brazilian Journal of Medical and Biological Research, v. 42, p. 921-929, 2009.
vii. Ferreira W ; Barbosa R ; Nascimento T ; Moreira. L ; Oliveira D ; SOUZA, Andrelina Noronha Coelho de ; MAGALHÃES, PJC ; LAHLOU, S ; CARDOSO, José Henrique Leal . Effects of 1,8-cineole on electrophysiological parameters of neurons of rat superior cervical ganglion. Clinical and Experimental Pharmacology & Physiology, v. 36, p. 1068-73, 2009.
viii. BASTOS, Vasco Pinheiro Diogenes ; BRITO, Teresinha Silva de ; BATISTA- LIMA, F. J. ; PINHO, J. P. M. ; LAHLOU, S ; MATOS, Francico Jose de Abreu ; SANTOS, AA ; MAGALHÃES, PJC . Inhibitory effect of 1,8-cineole on guinea pig airway challenged with ovalbumin involves a preferential action on electromechanical coupling. Clinical and Experimental Pharmacology & Physiology, v. 36, p. 1120-6, 2009.
ix. PORTO, N. P. C. ; JUCÁ, Davi Mathews ; LAHLOU, S ; COELHO-DE-SOUZA, AN ; DUARTE, Gloria Isolina Buentes Pinto ; MAGALHÃES, PJC . Effects of K+ channels inhibitors on the cholinergic relaxation of the isolated aorta of adult offspring rats exposed to maternal diabetes. Experimental and Clinical Endocrinology & Diabetes, 2009 (in press).
x. Leonhardt, V. ; LEAL-CARDOSO, JH ; LAHLOU, S ; ALBUQUERQUE, Aline Alice Cavalcante de ; PORTO, R. S. ; CELEDONIO, N. R. ; OLIVEIRA, A. C. ; MAGALHÃES, PJC ; DUARTE, Gloria Isolina Boentes Pinto ; COELHO-DE-SOUZA, AN . Antispasmodic effects of the essential oil of Pterodon polygalaeflorus and its main constituent b-caryophyllene on rat isolated ileum. Fundamental & Clinical Pharmacology, 2009 (in press).
xi. Moreira-Lobo DC, Linhares-Siqueira ED, Cruz GM, Cruz JS, Carvalho-de-Souza JL, Lahlou S, Coelho-de-Souza AN, Barbosa R, Magalhães PJ, Leal-Cardoso JH. Eugenol modifies the excitability of rat sciatic nerve and superior cervical ganglion neurons. Neurosci Lett. 2010
xii. Lima FJ, Brito TS, Freire WB, Costa RC, Linhares MI, Sousa FC, Lahlou S, Leal-Cardoso JH, Santos AA, Magalhães PJ. The essential oil of Eucalyptus tereticornis, and its constituents alpha- and beta-pinene, potentiate acetylcholine-induced contractions in isolated rat trachea. Fitoterapia. 2010 Mar 17,2010 Mar 26;472(3):220-4
xiii. Cristino-Filho, G. ; Leal, P.R.L. ; Lira, G.H.S. ; Souza, S.G. ; Rola, F.H. ; Oliveira, R.B. ; Souza, M.A.N. ; Santos, A. A. . Acute intracranial hypertension increases gastric tonus in anesthetized rats. Autonomic Neuroscience, v. 146, p. 95-101, 2009.
xiv. Albuquerque Filho, F.L. ; Macedo, Geraldo Munguba ; Santos, A.A. ; Rodrigues, L.M. ; Oliveira, R.B. ; Souza, M.A.N. . Stapled haemorrhoidopexy decreases transiently rectal compliance and sensitivity threshold. Colorectal Disease, v. XXX, p. x, 2009.
xv. Bruin, Veralice Meireles Sales de ; Noronha, AC ; Souza, MAN ; Araújo, RP ; Mota, RMS ; Bruin, PFC . Gastroesophageal reflux and obstructive sleep apnea in childhood. International Journal of Pediatric Otorhinolaryngology, v. 73, p. 383-389, 2009.
xvi. Peixoto Júnior, A.A. ; Teles, B.C.V ; Castro, E.F.B. ; Santos, A.A. ; de Oliveira, G.R. ; Ribeiro, R.A.; Rola, F.H. ; Gondim, F.A.A. . Vincristine delays gastric emptying and gastrointestinal transit of liquid in awake rats. Brazilian Journal of Medical and Biological Research, v. 42, p. 567-573, 2009.
xvii. ARCANJO, F.P.N.; Amancio, O.M.S.; Pinto, V.P.T. Effect of a beverage fortified with evaporated sugarcane juice on hemoglobin levels in preschool children. Pan American Journal of Public Health v. 26, p. 350-354, 2009.
xviii. PINTO, V.P.T.; Nascimento, K.S.; SAMPAIO, A.H. ; TEIXEIRA, E.H.; Teixeira, A.H.; CAVADA, B.S.; Debray, H. Lectins from the red marine algal species Bryothamnion seaforthii and Bryothamnion triquetrum as tools to differentiate human colon carcinoma cells. Advances in Pharmacological Sciences, v. 2009, p. 1-7, 2009.
xix. PALHETA JÚNIOR, Raimundo Campos ; Rola, Francisco Hélio ; LIRA, Gislano Heverton Soares de ; Gomes, Dayane Aparecida ; CARVALHO, Fernando Mota ; Elias, Lucila Leico Kagohara ; Antunes-Rodrigues, José ; OLIVEIRA, Ricardo Brandt de ; Santos, A.A. . Atrial stretch increases the gastric tonus of anesthetized rats. Life Sciences (1973), 2010.
xix. GOMES, A. S. ; Gadelha, G G ; Lima S J ; GARCIA, J. A. ; Medeiros, Jand Venes Rolim ; LIMA, A. A. M. ; Havt, A ; RIBEIRO, R. A. ; BRITO, G. A. C. ; Souza, M. H. L. P. . Gastroprotective effect of heme-oxygenase 1/biliverdin/CO pathway in ethanol-induced gastric damage in mice. European Journal of Pharmacology, 2010.
xix. JUNQUEIRA JÚNIOR, J. ; LIMA-JÚNIOR RCP ; MEDEIROS, J. R. ; BRITO, G. A. C. ; RIBEIRO, R. A. ; SOUZA, M. H. L. P. . Role of capsaicin sensitive primary afferent neurons and non-protein sulphydryl groups on gastroprotective effect of amifostine against ethanol-induced gastric damage in rats. Digestive Diseases and Sciences, 2010.
xix. Leal-Cardoso, JH, Lahlou S, Weinreich D, Magalhães PJC. The essential oil of Croton nepetaefolius selectively blocks histamine-augmented neuronal excitability in guinea-pig celiac ganglion. J Pharm Pharmacol, 2010.
Book chapters
SANTOS, A. A. . Motilidade gastrintestinal. In: Rui Curi; Joaquim Procópio Araújo Filho. (Org.). Fisiologia Básica. 1 ed. Rio de Janeiro: Guanabara Koogan, 2009, v. Cap43, p. 609-624.
RIBEIRO, R. A. ; VALE, M. L. ; Souza, M H L P . ANTIINFLAMATÓRIOS NÃO HORMONAIS E COXIBES. In: Onofre Alves Neto; Carlos Maurício de Castro Costa, José Tadeu T. de Siqueira, Manoel Jacobsen Teixeira. (Org.). DOR PRINCÍPIOS E PRÁTICA.. Porto Alegre: Artmed, 2009, v. 1, p. 1056-1073.
Souza, MAN. Abordagem do paciente com disfagia. In: José Milton de Castro Lima. (Org.). Gastroenterologia. Fortaleza: Edições UFC, 2009.
Article in Science Education (Physiology)
Souza, M. A. N.; Souza, M.H.L.P.; Palheta, R.C.; Cruz, P.R.M.; Medeiros, B.A.; Rola, F.H.; Magalhães, P.J.C.; Troncon, L.E.A. ; Santos, A.A. Evaluation of gastrointestinal motility in awake rats: a learning exercise for undergraduate biomedical students. Advances in Physiology Education, v. 33, p. 343-348, 2009.