Thematic II  -  Gastric Cancer and Ulcers

Participants:

Dulciene Queiroz,   Gifone Aguiar Rocha,   Lúcia Libanez Bessa C. Braga,  Vietla Satyanarayana Rao,   Gifone Aguiar Rocha

The second thematic proposed to screen and identify markers for prevention and treatment of gastric cancer and ulcers, for which we give the following results for the year 2009/2010:

Goals:

 Identify a typical cytokine profile associated with distal gastric carcinoma that will direct our investigation to possible genetic mutations that might be responsible for the increased risk to develop the disease

 Pre-clinical studies of compounds isolated from medicinal plants from the Northeast in experimental models of gastric ulcer and inflammatory bowel diseases.

 Identify a specific cytokine profile that allows us to characterize individuals at risk of developing gastric cancer and that way, guiding our investigation of genetic mutations associated with the disease

 To establish the efficacy of diterpenos alfa, beta, amirine, centipedic acid and lactone from hawtriwaic acid in experimental models of gastric ulcer and inflammatory bowel diseases.

Publications

i.  QUEIROZ DMM, OLIVEIRA AG, SARAIVA IEB, ROCHA GA, ROCHA AMC, SANNA MGP, GUERRA JB, DANI R, FERRARI MLA, CASTRO LPF. Immune response and gene polymorphism profiles in Crohn's disease and ulcerative colitis. Inflammatory Bowel Diseases. 2009: 353-358.

ii.  QUEIROZ DM, SARAIVA IE, ROCHA GA, ROCHA AM, GOMES LI, MELO FF, BITTENCOURT PF. IL2-330G polymorphic allele is associated with decreased risk of Helicobacter pylori infection in adulthood. Microbes Infect. 2009; 1:80-7.

iii.   OLEASTRO M, CORDEIRO R, YAMAOKA Y, QUEIROZ D, MÉGRAUD F, MONTEIRO L, MÉNARD A. Disease association with two Helicobacter pylori duplicate outer membrane protein genes, homB and homA. Gut Pathog. 2009 Jun 22;1(1):12

iv.   OLEASTRO M, CORDEIRO R, MÉNARD A, YAMAOKA Y, QUEIROZ D, MÉGRAUD F, MONTEIRO L. Allelic diversity and phulogeny of homB, a novel co-virulence marker of Helicobacter pylori. BMC Microbiology, 2009, 9:248. doi: 10.1186/1471-2180-9-248

v.  QUEIROZ DMM, CUNHA RPA, SARAIVA IB, ROCHA AMC. Helicobacter pylori virulence factors as tools to study human migrations. Toxicon DOI: 10.1016/j.toxicon.2010.01.018

vi.   Protective effect of anacardic acids from cashew (Anacardium occidentale) on ethanol-induced gastric damage in mice. Morais TC, Pinto NB, Carvalho KM, Rios JB, Ricardo NM, Trevisan MT, Rao VS, Santos FA. Chem Biol Interact. 2010 Jan 5;183(1):264-9.

vii.   Betulinic acid, a natural pentacyclic triterpenoid, prevents abdominal fat accumulation in mice fed a high-fat diet. de Melo CL, Queiroz MG, Arruda Filho AC, Rodrigues AM, de Sousa DF, Almeida JG, Pessoa OD, Silveira ER, Menezes DB, Melo TS, Santos FA, Rao VS. J Agric Food Chem. 2009 Oct 14;57(19):8776-81

viii.   Gastroprotective effect of lupeol on ethanol-induced gastric damage and the underlying mechanism. Lira SR, Rao VS, Carvalho AC, Guedes MM, de Morais TC, de Souza AL, Trevisan MT, Lima AF, Chaves MH, Santos FA. Inflammopharmacology. 2009 Aug;17(4):221-8.

ix.   In vitro and in vivo anti-Helicobacter pylori activity of Calophyllum brasiliense Camb. Souza Mdo C, Beserra AM, Martins DC, Real VV, Santos RA, Rao VS, Silva RM, Martins DT. J Ethnopharmacol. 2009 Jun 25;123(3):452-8.

Book chapters

ROCHA AMC, ROCHA GA, SOARES TF, QUEIROZ DMM. Investigação Laboratorial do paciente com infecção por Helicobacter pylori. In: Erichsen E.S. (org). Medicina Laboratorial para o Clínico. 1ª ED. Belo Horiozonte. Coopmed. 2009. pág 15-160

Brasil NGPS ; SILVEIRA, E.R.; CAVALCANTI, B.; Ferreira JRO ; SANTOS, F.A.; Rao VS; COSTA-LOTUFO, L.; MORAES, M.; PESSOA, C. Chemistry and Pharmacology of Copaifera langsdorffii Desf.. In: A.s.Awaad; J.N.Govil.; V.K.Singh. (Org.). Recent Progress in Medicinal Plants. 1 ed. New Delhi: Studium Press, 2009, v. 27, p. 241-266