Thematic I  -  Diarrheal diseases malnutrition and oral health

Goals   |   Publications  |   Books  |   Book chapters

Participants:

Aldo AM Lima,  Reinaldo B. Oriá, Gerly AC Brito, Alexandre Havt Bindá, Alberto M Soares, Antônio AC Ribeiro, Helíada Chaves,  Helena SA Monteiro, Marcelo G Oliveira,  Maria Cecília F Azoubel,  Renata C Leitão,  Vilma Lima,   Geanne M. A. Cunha,  Augusto Coppi Ribeiro, USP, Marcelo Ganzarolli de Oliveira, UNICAMP,  Júlio César Goes Ferreira, UFC/Química,  Richard L. Guerrant--Uva-USA, Michael Vitek, Duke University-USA,Brent Polk, Vanderbilt, USA

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The thematic aimed at developing the following goals, for which we have reached the following results during the year 2009:

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Goals:

 To determine the diarrhea etiology afflicting the semiarid children, develop molecular methods for rapid and sensitive etiological diagnosis of the main causes of child diarrhea and thus the bio-product development. Development of nutritional bio-products through the interaction between the Institute and enterprises, represented by Nutrasol, biotechnology and industry.

  Investigate the production of PTX3 in human intestinal cell lines (Caco-2, T-84) and rat intestinal cell lines (IEC-6) in vitro following exposure to bacterial toxins involved in diarrheal diseases.

  Evaluate the role of PTX 3 as an inflammation and severity marker of diarrheal diseases

  Develop stable bio-products and glutamine and arginine derivates to be used as nutritional supplementation, oral hydration and parental nutrition. These bio-products will be developed through patents obtained by the Institute and applied to projects of the UPC (Clinical Research Unit)

  Study the modulation effect via adenosine/inosine in human intestinal cell lines (Caco-2, T-84) and rat intestinal cell lines (IEC-6) in vitro following exposure to bacterial toxins and in vivo models

  Develop novel phospolipase A1 inhibitors for treatment of inflammatory diarrhea and malnutrition

  Study the modulation effect via adenosine/inosine in human intestinal cell lines (Caco-2, T-84) and rat intestinal cell lines (IEC-6) in vitro following exposure to bacterial toxins and in vivo models

  Modulation of the Adenosine/inosine via as a novel therapeutic approach for diarrheal diseases.

  Evaluate the biocompatibility e biofunctionality of new biomimetic substrate complexes, developed by the Universidade Federal do Ceara and the University of Campinas (UNICAMP), to be applied in tissue and bone Repair, and in the experimental periodontal disease and in humans with chronic periodontitis.

Publications

i.  Pinto, N.B. ; Morais, T.C. ; Carvalho, K.M.B. ; Silva, C.R. ; Andrade, G.M. ; Brito, G.A.C. ; Veras, M.L. ; Pessoa, O.D.L. ; Santos, F.A. Topical anti-inflammatory potential of Physalin E from Physalis angulata on experimental dermatitis in mice. Phytomedicine (Stuttgart), 10: 1016, 2010.

ii.  Sousa, Clauber M.; HAVT, Alexandre; Santos, Cláudia F.; Arnaud-Batista, F.J.; Cunha, Karina M.A.; Cerqueira, João Batista G.; Fonteles, Manassés C.; Nascimento, Nilberto R.F. The relaxation induced by uroguanylin and the expression of natriuretic peptide receptors in human corpora cavernosa. The Journal of Sexual Medicine (Print), p. 1-10, 2010.

iii.   Evangelista, Inez Liberato; Costa Martins, Alice Maria; Falcão Nascimento, Nilberto Robson; HAVT, Alexandre; Azul Monteiro Evangelista, Janaina Serra; Sá de Norões, Terentia Batista; TOYAMA, Marcos Hikari; Diz-Filho, Eduardo Brito; de Oliveira Toyama, Daniela; FONTELES, Manassés C. Renal and cardiovascular effects of Bothrops marajoensis venom and phospholipase A2. Toxicon (Oxford), v. 55, p. 1061-1070, 2010.

iv.   Gomes, Antoniella S; Gadelha, Gemima G; Lima, Samara J; Garcia, Joyce A; Medeiros, Jand Venes R; Havt, Alexandre; LIMA, Aldo Ângelo Moreira; RIBEIRO, Ronaldo Albuquerque; Cunha, Fernando Q.; Souza, Marcellus HLP. Gastro-protective effect of heme-oxygenase 1/biliverdin/co pathway in ethanol-induced gastric damage in mice.. European Journal of Pharmacology, v. 1, p. 1-1, 2010.

v.   de Freitas, MR ; de Castro Brito, GA ; de Carvalho, JV ; Gomes, RM ; Barreto Martins, MJ ; Ribeiro, RA. Light microscopy study of cisplatin-induced ototoxicity in rats. Journal of Laryngology and Otology, v. 123, p. 590, 2009.

vi.   Medeiros, J.V.R ; Bezerra, V.H ; Gomes, A.S ; Barbosa, A.L.R ; Lima-Junior, R.C.P ; Soares, P. M.G ; Brito, G.A.C ; Ribeiro, R.A ; CUNHA, F.Q. ; Souza, MHLP. Hydrogen sulphide prevents ethanol-induced gastric damage in mice: role of K+ATP channels and capsaicin-sensitive primary afferent neurons. Journal of Pharmacology and Experimental Therapeutics 152: 801, 2009.

vii.   Freitas, MR; Silva, VC; Brito, GAC ; Carvalho Junior, JV; Gomes Junior, RM; Ribeiro, RA. Distortion-product otoacoustic emissions and auditory brainstem responses sensitivity assessment in cisplatin-induced ototoxicity in rats. Brazilian Journal of Otorhinolaryngology v. 75, p. 476-484, 2009

viii.   Moore SR, Lima NL, Soares AM, Oria RB, Pinkerton RC, Barrett LJ, Guerrant RL, Lima AAM. Effects of prolonged episodes of acute diarrhea on childhood growth and risk of persistent diarrhea in northeast Brazil: a community birth cohort study. Gastroenterology 000:000-000, 2010 (In Press).

ix.   Quetz JS, Lima IFN, Binda AH, Carvalho EB, Lima NL, Soares AM, Mota RMS, Guerrant RL, Lima AAM. Campylobacter jejuni and Campylobacter coli in children from communities in Northeastern Brazil: molecular detection, intestinal inflammation and nutritional status. Diagn Microbiol Infect Dis 00:000-000, 2010 (In Press).

x.   Ladd FV, Ladd AA, Ribeiro AA, Costa SB, Coutinho BP, Feitosa GA, de Andrade GM, Maurício de Castro-Costa C, Magalhães CE, Castro IC, Oliveira BB, Guerrant RL, Lima AA, Oriá RB. Zinc and glutamine improve brain development in suckling mice subjected to early postnatal malnutrition. Nutrition. 2010 Apr 3.

xi.   Oriá RB, Patrick PD, Oriá MO, Lorntz B, Thompson MR, Azevedo OG, Lobo RN, Pinkerton RF, Guerrant RL, Lima AA. ApoE polymorphisms and diarrheal outcomes in Brazilian shanty town children. Braz J Med Biol Res. 2010 Feb 5.

xii.  LIMA, A.Â.M., Soares, AM, MOTA, RM, Maciel BL, BARRET, L.J., Fitzgerald RP, BLANER, W. S., GUERRANT, R.L. Effects of Vitamin A Supplementation on intestinal barrier function, growth, total parasitic and specific Giardia spp infections in Brazilian children: a prospective randomized, double-blind, placebo-controlled trial. Journal of Pediatric Gastroenterology and Nutrition. , v.50, p.309 - 315, 2010.

xiii.   Coopeland C, Beers BB, Thompson MR, Fitzgerald RP, BARRETT, L. J., Alencar S, LIMA, A. Â. M., GUERRANT, R.L. Faecal contamination of drinking water in a Brazilian shanty town: importance of household storage and new human faecal. Journal of Water and Health. v.7, p.324 - 331, 2009.

xiv.   FONTELES, M.C., HAVT, A, Prata, PH, MONTEIRO, HS, LIMA, A.Â.M., Jorge, AR, Santos, CF, GREENBERG, R.N., Nascimento NR. High-salt intake primes the rat kidney to respond to a subthreshoul uroguanylin dose during ex vivo renal perfusion. Regulatory Peptides. v.27, p.6 - 13, 2009.

xv.   FAÇANHA, MC, Gondim AM, Pinheiro VG, Peloquin CA, GUERRANT, RL, LIMA, A.Â.M. Intestinal barrier function and serum concentrations of rifampin, isoniazid and pyrazinamide in patients with pulmonary tuberculosis. The Brazilian Journal of Infectious Diseases. , v.13, p.210 - 217, 2009.

xvi.   ORIÁ, RB, COSTA, CMC, LIMA, A.Â.M., PATRICK, PD, GUERRANT, R.L. Semantic fluency: a sensitive marker for cognitive impairment in children with heavy diarrhea burdens?. Medical Hypotheses. , v.73, p.682 - 686, 2009.

xvii. Barroso, EC, PINHEIRO, VG, FAÇANHA, MC, Carvalho, MR, Moura, ME, CAMPELO, C.L., PELOQUIN, CA, GUERRANT, R.L., LIMA, A.Â.M. Serum concentrations of rifampin, isoniazid and intestinal absorption, permeability in patients with multidrug resistant tuberculosis. The American Journal of Tropical Medicine and Hygiene. , v.81, p.322 - 329, 2009.

xviii.    Shamir ER, Warthan M, Brown SP, Nataro JP, Guerrant RL, Hoffman PS. Nitazoxanide inhibits biofilm production and hemagglutination by enteroaggregative Escherichia coli strains by blocking assembly of AafA fimbriae. Antimicrob Agents Chemother. 2010 Apr;54(4):1526-33.

xix.    Pawlowski SW, Archbald-Pannone L, Carman RJ, Alcantara-Warren C, Lyerly D, Genheimer CW, Gerding DN, Guerrant RL. Elevated levels of intestinal inflammation in Clostridium difficile infection associated with fluoroquinolone-resistant C. difficile. J Hosp Infect. 2009 Oct;73(2):185-7.

xx.    Mintz ED, Guerrant RL. A lion in our village--the unconscionable tragedy of cholera in Africa. N Engl J Med. 2009 Mar 12;360(11):1060-3.

xxi.   MARTINS, A. M. C. ; BARBOSA, P. S. F. ; SOUSA, D. F. ; ALVES, C. D. ; MENEZES, D. B. ; Lima C ; FONTELES, M. C. ; LOPES-FERREIRA, M. ; MONTEIRO, H. S. A. . Antivenom action on the renal effects induced by Thalassophryne nattereri venom.. The Journal of Venomous Animals and Toxins Including Tropical Diseases (Online), v. 15, p. 125-135, 2009.

xxii.   MARTINS, R. D. ; ALVES, R. S. ; MARTINS, A.M.C. ; BARBOSA, P. S. F. ; EVANGELISTA, J. S. A. M. ; Evangelista, J. J. F. ; Ximenes, R. M. ; TOYAMA, M. H. ; TOYAMA, D. O. ; Souza, A.J.F. ; Orts, D.J.B. ; MARANGONI, S. ; MENESES, D.B. ; FONTELES, M. C. ; MONTEIRO, H. S. A. . Purification, characterization and biological effects of phospholipase A2 from sea anemone Bunodosoma caissarum. Toxicon (Oxford), v. 54, p. 413-420, 2009.

Books

Bases Farmacológicas e Usos Clínicos dos Antimicrobianos. Aldo A. M. Lima Editor, 1ª. Edição, 2010. (in development).

Book chapters

LIMA, A.A.M.; GUERRANT, R.L. Cryptosporidiosis. In: Goldman; Ausiello. (Org.). Cecil Textbook of Medicine. 23 ed.: 2010, p. 0000-0000. In Press

CARVALHO, EM; LIMA, A.Â.M. Schistosomiasis. In: Goldman; Ausiello. (Org.). Cecil Texbook of Medicine. 23 ed.: 2010, p. 0000-0000. In Press

LIMA, A.Â.M.; SAMIE, AMIDOU; GUERRANT, R.L. Cryptosporidiosis. In: Richard L. Guerrant; David H. Walker; Peter F. Weller. (Org.). Tropical Infectious Diseases. 3 ed.: 2010, v. 2, p. 0000-0000. In Press

LIMA, A.Â.M.; GUERRANT, R.L. Inflammatory Enteritis. In: Gerald L. Mandell; John E. Bennett; Raphael Dolin. (Org.). Principles and Practice of Infectious Diseases. 7th Edition: 2010, v. 2, p. 1389-1398.

LIMA AAM, GUERRANT RL. “Cholera” in the Oxford Textbook of Medicine, 5th Edition. Edited by Warrell DA, Cox TM, Firth JD, Benz Jr. EJ. 2010, p.754-759.

ORIÁ, RB, LIMA, AAM, GUERRANT, RL. DALYs and diarrhea In: Handbook of disease burdens and quality of life measures, Springer Edited by Victor R. Preedy and Ronald Ross Watson, 1st edition, 2010.