Biomarkers and Bioproducts Developed and / or Validated

See the Tables 1 to 8 showed below describe the bio-markers developed and / or validated in the INCT-IBISAB and already available for use as DNA probes for the diagnosis of intestinal infection, determination of virulence factors and biological studies, according to the intrinsic goals INCT-IBISAB or those networks, RECODISA and MAL_ED which were previously described.

Among these bio-markers, it is worth highlighting: (a) dosage of lactoferrin for enteropathy and intestinal inflammation (Sean et al. Gastroenterology, 2010, In Press), and (b) the test of lactulose: mannitol to determine the absorptive area, permeability and intestinal damage (Lee et al. Gastroenteol Ped J Nutr 50: 309, 2009). Furthermore, the INCT-IBISAB participated in the context of the international RECODISA, the development of two new bio-products, HLZ and hG-CSF produced in milk of transgenic goats, which are currently undergoing tests in vitro and in vivo for evaluation of their biological effects, toxicity and effectiveness in preventive and curative therapy of diarrhea caused by bacterial agents.